Tomasini C, Quaglino P, Novelli M, Fierro M T
Department of Medical and Surgical Specialities, University of Turin, Italy.
Am J Dermatopathol. 1998 Aug;20(4):417-21. doi: 10.1097/00000372-199808000-00018.
Aleukemic leukemia cutis is a rare condition characterized by the infiltration of the skin by leukemic cells before their appearance in the peripheral blood. The authors report a case of aleukemic leukemia cutis in a 30-year-old seemingly healthy man who presented with multiple skin papulonodular lesions and lack of peripheral blood involvement. Histopathologically, the skin infiltrates showed prominent granulomatous features that masked the underlying malignant process. Immunophenotypic studies of skin and bone marrow infiltrates revealed the myelomonocytic lineage of the atypical cells, consistent with M4 acute myelomonocytic leukemia. The authors emphasize the value of immunohistochemical studies in diagnosing a cutaneous atypical infiltrate and discuss problems of histopathologic differential diagnosis.
无白血病性白血病性皮肤浸润是一种罕见病症，其特征为白血病细胞在出现在外周血之前先浸润皮肤。作者报告了一例发生在一名30岁看似健康男性身上的无白血病性白血病性皮肤浸润病例，该患者表现为多发性皮肤丘疹结节性病变且外周血未受累。组织病理学上，皮肤浸润显示出显著的肉芽肿特征，掩盖了潜在的恶性过程。对皮肤和骨髓浸润进行的免疫表型研究揭示了非典型细胞的髓单核细胞系，与M4急性髓单核细胞白血病一致。作者强调免疫组化研究在诊断皮肤非典型浸润中的价值，并讨论了组织病理学鉴别诊断的问题。
