Yoshida H, Takakura N, Hirashima M, Kataoka H, Tsuchida K, Nishikawa S, Nishikawa S
Department of Molecular Genetics, Faculty of Medicine, Kyoto University, Japan.
Dev Comp Immunol. 1998 May-Jun;22(3):321-32. doi: 10.1016/s0145-305x(98)00008-1.
Three receptor tyrosine kinases of the PDGF receptor family (RTKP) that clustered within 1000 Kb of the mouse chromosome 5 constitute an interesting unit that are expressed in three distinct cell lineages essential for constructing hematopoietic tissues. Namely, the c-kit gene that is expressed in hematopoietic stem cells is flanked by pdgfr alpha and flk genes expressed respectively in stromal cells and vascular endothelial cells. In this article, we review our results on their expression in the embryonic hematopoietic tissues. We found that co-expression of Flkl and c-Kit was frequently detected either in vascular endothelial cells or hematopoietic cells in the early hematopoietic tissues. On the other hand, the three RTKPs are expressed in different cell lineages in the fetal liver. On the basis of this finding, we propose two modes of embryonic hematopoiesis; hematogenic angiopoiesis and hematopoiesis.
血小板衍生生长因子受体家族（RTKP）的三种受体酪氨酸激酶聚集在小鼠5号染色体的1000千碱基对范围内，构成了一个有趣的单元，它们在构建造血组织所必需的三种不同细胞谱系中表达。具体而言，在造血干细胞中表达的c-kit基因两侧分别是在基质细胞和血管内皮细胞中表达的pdgfrα和flk基因。在本文中，我们回顾了它们在胚胎造血组织中表达的研究结果。我们发现，在早期造血组织的血管内皮细胞或造血细胞中经常检测到Flkl和c-Kit的共表达。另一方面，这三种RTKPs在胎肝的不同细胞谱系中表达。基于这一发现，我们提出了两种胚胎造血模式：造血血管生成和造血。
