Sobotta Lukasz, Skupin-Mrugalska Paulina, Mielcarek Jadwiga, Goslinski Tomasz, Balzarini Jan
Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
Mini Rev Med Chem. 2015;15(6):503-21. doi: 10.2174/1389557515666150415151505.
Viruses cause many diseases in humans from the rather innocent common cold to more serious or chronic, life-threatening infections. The long-term side effects, sometimes low effectiveness of standard pharmacotherapy and the emergence of drug resistance require a search for new alternative or complementary antiviral therapeutic approaches. One new approach to inactivate microorganisms is photodynamic antimicrobial chemotherapy (PACT). PACT has evolved as a potential method to inactivate viruses. The great challenge for PACT is to develop a methodology enabling the effective inactivation of viruses while leaving the host cells as untouched as possible. This review aims to provide some main directions of antiviral PACT, taking into account different photosensitizers, which have been widely investigated as potential antiviral agents. In addition, several aspects concerning PACT as a tool to assure viral inactivation in human blood products will be addressed.
病毒可引发人类的多种疾病，从相对无害的普通感冒到更为严重或慢性的、危及生命的感染。长期的副作用、标准药物疗法有时较低的有效性以及耐药性的出现，都需要寻找新的替代或补充性抗病毒治疗方法。一种使微生物失活的新方法是光动力抗菌化学疗法（PACT）。PACT已发展成为一种使病毒失活的潜在方法。PACT面临的巨大挑战是开发一种方法，能够有效使病毒失活，同时尽可能不影响宿主细胞。本综述旨在考虑不同的光敏剂，提供抗病毒PACT的一些主要方向，这些光敏剂已作为潜在的抗病毒剂得到广泛研究。此外，还将探讨PACT作为确保人血制品中病毒失活工具的几个方面。
