Baker G A, Smith D F, Jacoby A, Hayes J A, Chadwick D W
University Department of Neurosciences, Walton Centre for Neurology and Neurosurgery, Liverpool, UK.
Seizure. 1998 Jun;7(3):201-5. doi: 10.1016/s1059-1311(98)80036-8.
The purpose of the study was to examine the psychometric properties of the revised Liverpool Seizure Severity Scale. The scale has been adapted to increase its content validity and its potential for detecting change attributable to antiepileptic drug treatment. Ninety-seven patients completed the revised scale of which 32 completed it for both major and minor seizures. Reliability of the revised scale was conducted using assessment of internal consistency and test-retest. T-tests were conducted to assess the ability of patients to differentiate between major and minor seizures on scores of the seizure-severity scale. The psychometric properties of the scale were not adversely affected by either the increase in the number of items or the additional response scores. Patients completing the two scales of major and minor seizures were able to reliably differentiate between the two. We have attempted to improve the Liverpool Seizure Severity Scale in order to enhance its reliability, validity and sensitivity to change. The amendments we have made have not adversely affected its psychometric properties and we hope that it will make it more acceptable for use in clinical trials of new antiepileptic drug treatment. The revised scale is currently being applied to a number of clinical trials.
该研究的目的是检验修订后的利物浦癫痫发作严重程度量表的心理测量特性。该量表已进行调整，以提高其内容效度及其检测抗癫痫药物治疗所致变化的潜力。97名患者完成了修订后的量表，其中32名患者对大发作和小发作均完成了该量表。通过评估内部一致性和重测来进行修订后量表的信度分析。进行t检验以评估患者在癫痫发作严重程度量表得分上区分大发作和小发作的能力。量表的心理测量特性未受到项目数量增加或额外反应得分的不利影响。完成大发作和小发作两个量表的患者能够可靠地区分两者。我们试图改进利物浦癫痫发作严重程度量表，以提高其信度、效度和对变化的敏感性。我们所做的修订并未对其心理测量特性产生不利影响，我们希望它在新型抗癫痫药物治疗的临床试验中更易于被接受。修订后的量表目前正在应用于多项临床试验。
