de la Motte D J, Allt G
Acta Neuropathol. 1976 Sep 15;36(1):9-19. doi: 10.1007/BF00685143.
Electron microscope observations were made of rat peroneal nerve after crushing using intravenously injected horseradish peroxidase (HRP) as a tracer protein to indicate changes in vascular permeability. At 1/2 h and 2 d after the crush there was gross leakage of HRP from damaged capillaries at the site of injury but none from vessels above or below this. Ultrastructurally vessels at the site of crush showed broken and separated endothelial cells. Proximally and distally there was little abnormal in the vessel walls; vesicles containing HRP were absent and tight-junctions between cells remained intact. Twenty-one days after the crush, leakage of HRP was found both at the site of crush and along the distal segment. The only change in vessel walls was an obvious increase in vesicles filled with HRP. Tracer was also found both in perivascular locations and throughout the endoneurial space.
使用静脉注射辣根过氧化物酶（HRP）作为示踪蛋白来指示血管通透性的变化，对挤压后的大鼠腓总神经进行了电子显微镜观察。挤压后半小时和2天时，损伤部位受损毛细血管有大量HRP渗漏，但损伤部位上方和下方的血管无渗漏。超微结构上，挤压部位的血管显示内皮细胞破裂和分离。在近端和远端，血管壁几乎没有异常；含有HRP的囊泡不存在，细胞间紧密连接保持完整。挤压后21天，在挤压部位和远端节段均发现HRP渗漏。血管壁的唯一变化是充满HRP的囊泡明显增加。在血管周围位置和整个神经内膜间隙也发现了示踪剂。
