Goossens M M, Feldman E C, Nelson R W, Theon A P, Koblik P D, Elliott D A, Rutteman G R
Veterinary Medical Teaching Hospital, CA, USA.
J Am Vet Med Assoc. 1998 Aug 1;213(3):374-6.
Acromegaly was diagnosed in 3 cats with insulin-resistant diabetes mellitus (DM) on the basis of history and physical examination findings, which ruled out other causes of insulin-resistant DM, and by documenting high plasma concentrations of growth hormone. Computed tomography revealed a mass in the area of the pituitary gland in each cat. Pituitary gland tumors were irradiated with cobalt 60, and none of the cats developed complications to radiotherapy. Each cat received a total dose of 48 Gy of cobalt 60 during 12 treatments. After completion of radiotherapy, insulin requirements were less for all cats, although in 1 cat, this improvement was transient. Diabetes mellitus resolved in 2 of 3 cats. After treatment, decreases in insulin requirements correlated with decreases in plasma growth hormone concentrations in 2 of 3 cats in which DM resolved. On the basis of these findings, irradiation of pituitary gland tumors appears to be a treatment option for cats with acromegaly.
根据病史和体格检查结果，排除了胰岛素抵抗性糖尿病（DM）的其他病因，并通过记录高血浆生长激素浓度，在3只患有胰岛素抵抗性糖尿病的猫中诊断出肢端肥大症。计算机断层扫描显示每只猫的垂体区域有一个肿块。用钴60对垂体肿瘤进行照射，没有一只猫出现放疗并发症。每只猫在12次治疗中接受了总量为48 Gy的钴60照射。放疗结束后，所有猫的胰岛素需求量都减少了，尽管有1只猫的这种改善是短暂的。3只猫中有2只的糖尿病得到缓解。在治疗后，3只糖尿病得到缓解的猫中有2只胰岛素需求量的减少与血浆生长激素浓度的降低相关。基于这些发现，垂体肿瘤照射似乎是肢端肥大症猫的一种治疗选择。
