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[麻疹免疫刺激复合物的抗原活性]

[Antigenic activity of measles immunostimulating complex].

作者信息

Mamaeva T A, Tikhonova N T, Starov A I, Naumova M A, Vysotskiĭ V V

出版信息

Vopr Virusol. 1998 May-Jun;43(3):127-9.

PMID:9702812
Abstract

The liposomal technology for preparing the immunostimulating complex (ISCOM) helped obtain a complex measles preparation whose antigens are represented by the structural proteins of measles virus in the bilayer phosphate-lipid membrane. Immunization of mice with the resultant preparation induced antimeasles antibodies with the maximum titer of antihemagglutinins 1:640 and of antihemolysins 1:1280. The biological activity of antibodies was confirmed in the neutralization test.

摘要

用于制备免疫刺激复合物(ISCOM)的脂质体技术有助于获得一种复合麻疹制剂,其抗原由双层磷酸脂质膜中的麻疹病毒结构蛋白呈现。用所得制剂免疫小鼠可诱导产生抗麻疹抗体,抗血凝素的最大滴度为1:640,抗溶血素的最大滴度为1:1280。抗体的生物活性在中和试验中得到证实。

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