Carpenter M A, Trunkey D D, Holcroft J
Circ Shock. 1978;5(2):163-72.
Ionized calcium (Ca2+) and ionized magnesium (Mg2+) are important intracellular "second messengers" and control excitation-contraction coupling excitation-secretion coupling, oxidative phosphorylation, and mitochondrial acid-base balance. This study examines the effect of hemorrhagic shock on serum Ca2+ and Mg2+. Eight baboons were subjected to severe hemorrhagic shock and then resuscitated. Ca2+ was measured by the Orion SS-20 flowthrough calcium electrode and Mg2+ was calculated by the method of Killen. Other measurements included: total calcium, bound calcium, total magnesium, bound magnesium, albumin, globulin, total protein, phosphate, pH, and hematocrit. This study shows that there are significant disturbances of Ca2+ and Mg2+ during resuscitation from hemorrhagic shock. These disturbances may in part explain cellular dysfunctions during shock, including decreased myocardial contractility, inappropriate secretion of endocrine cells, decrease in oxidative phosphorylation, and mitochondrial acidosis.
离子钙（Ca2+）和离子镁（Mg2+）是重要的细胞内“第二信使”，控制兴奋-收缩偶联、兴奋-分泌偶联、氧化磷酸化以及线粒体酸碱平衡。本研究检测失血性休克对血清Ca2+和Mg2+的影响。八只狒狒经历严重失血性休克后进行复苏。Ca2+通过奥立龙SS-20流通式钙电极测定，Mg2+通过基伦方法计算。其他测量指标包括：总钙、结合钙、总镁、结合镁、白蛋白、球蛋白、总蛋白、磷酸盐、pH值和血细胞比容。本研究表明，失血性休克复苏过程中Ca2+和Mg2+存在显著紊乱。这些紊乱可能部分解释休克期间的细胞功能障碍，包括心肌收缩力下降、内分泌细胞分泌异常、氧化磷酸化降低以及线粒体酸中毒。
