Trunkey D, Carpenter M A, Holcroft J
J Trauma. 1978 Mar;18(3):166-72.
Ionized calcium (Ca2+) and ionized magnesium (Mg2+) are important intracellular "second messengers" and control exictation-contraction coupling, excitation-secretion, oxidative phosphorylation, and mitochondrial acid-base balance. The present study examines the effect of septic shock on serum (Ca2+) and (Mg2+). Five adult female baboons were subjected to live E. coli septic shock and then resuscitated. Three baboons served as controls. Ca2+ was measured by the Orion SS-20 flow-through calcium electrode and Mg2+ calculated by the method of Killen. Other measurements included: total calcium, bound calcium, total magnesium, bound magnesium, phosphate, albumin, globulin, hemotocrit, and total protein. This study shows that there are significant disturbances of Ca2+ and Mg2+ during septic shock in the baboon. These disturbances may in part explain cellular dysfunction during shock including: decreased myocardial contractility, inappropriate secretion of endocrine cells, decrease in oxidative phosphorylation, and mitochondrial acidosis.
离子钙（Ca2+）和离子镁（Mg2+）是重要的细胞内“第二信使”，控制兴奋-收缩偶联、兴奋-分泌、氧化磷酸化以及线粒体酸碱平衡。本研究检测脓毒性休克对血清（Ca2+）和（Mg2+）的影响。五只成年雌性狒狒遭受活大肠杆菌所致的脓毒性休克，随后进行复苏。三只狒狒作为对照。Ca2+通过奥立龙SS-20流通式钙电极测量，Mg2+采用基伦方法计算。其他测量指标包括：总钙、结合钙、总镁、结合镁、磷酸盐、白蛋白、球蛋白、血细胞比容和总蛋白。本研究表明，狒狒在脓毒性休克期间Ca2+和Mg2+存在显著紊乱。这些紊乱可能部分解释休克期间的细胞功能障碍，包括：心肌收缩力下降、内分泌细胞分泌异常、氧化磷酸化降低以及线粒体酸中毒。
