Chabolla D R, Maraganore D M, Ahlskog J E, O'Brien P C, Rocca W A
Department of Neurology, Mayo Clinic Jacksonville, Florida 32224, USA.
Mayo Clin Proc. 1998 Aug;73(8):724-7. doi: 10.4065/73.8.724.
To investigate whether subjects who experienced a reversible episode of drug-induced parkinsonism have an increased risk of subsequent Parkinson's disease.
We undertook a historical cohort study based on the medical records-linkage system of the Rochester Epidemiology Project in Olmsted County, Minnesota.
All subjects in whom drug-induced parkinsonism developed between 1955 and 1990 and was indexed in the medical records-linkage system were identified. In the 24 eligible subjects, follow-up for the subsequent development of Parkinson's disease consisted of a total of 192.7 person-years. The observed number of cases of Parkinson's disease was compared with the expected number of cases in an age- and sex-matched cohort from the general population.
In 2 of 24 subjects with drug-induced parkinsonism, Parkinson's disease later developed. A comparison with the expected number of cases in the general population (0.08) yielded a relative risk of 24.3 (95% confidence interval, 2.9 to 87.5; P = 0.006).
Our findings suggest that drug-induced parkinsonism is associated with an increased risk of Parkinson's disease. Clarification of the mechanisms of this association may have preventive implications.
研究经历药物性帕金森综合征可逆发作的受试者后续患帕金森病的风险是否增加。
我们基于明尼苏达州奥尔姆斯特德县罗切斯特流行病学项目的医疗记录链接系统进行了一项历史性队列研究。
确定了1955年至1990年间发生药物性帕金森综合征并在医疗记录链接系统中编目的所有受试者。在这24名符合条件的受试者中，对帕金森病后续发展的随访共计192.7人年。将观察到的帕金森病病例数与来自普通人群的年龄和性别匹配队列中的预期病例数进行比较。
在24名药物性帕金森综合征受试者中，有2名后来患上了帕金森病。与普通人群中的预期病例数（0.08）相比，相对风险为24.3（95%置信区间，2.9至87.5；P = 0.006）。
我们的研究结果表明，药物性帕金森综合征与帕金森病风险增加有关。阐明这种关联的机制可能具有预防意义。
