Koster R W, Wellens H J
Am J Cardiol. 1976 Oct;38(4):519-23. doi: 10.1016/0002-9149(76)90471-9.
Three cases are described with documented ventricular flutter and fibrillation during quinidine medication without concomitant digitalis therapy. In all three patients the arrhythmia developed while they were receiving moderate doses of quinidine. Although no changes in QRS width were observed after administration of quinidine, there was marked prolongation of the Q-T interval. The mechanism of development of ventricular flutter and fibrillation in patients taking quinidine may be similar to that in patients with the Q-T prolongation syndrome.
本文描述了3例在服用奎尼丁期间记录到室性扑动和颤动的病例，这些患者未同时接受洋地黄治疗。在所有3例患者中，心律失常均在接受中等剂量奎尼丁治疗时发生。虽然服用奎尼丁后QRS波宽度未观察到变化，但Q-T间期明显延长。服用奎尼丁患者发生室性扑动和颤动的机制可能与Q-T间期延长综合征患者相似。
