幽门螺杆菌感染与胃腺癌的关联。
Association of Helicobacter pylori infection with gastric adenocarcinoma.
作者信息
Lee B M, Jang J J, Kim J S, You Y C, Chun S A, Kim H S, Han H M, Ahn M Y, Byun S H
机构信息
Division of Toxicology, College of Pharmacy, Sung Kyun Kwan University, Suwon, Korea.
出版信息
Jpn J Cancer Res. 1998 Jun;89(6):597-603. doi: 10.1111/j.1349-7006.1998.tb03260.x.
Gastric adenocarcinoma is the most prevalent cancer in South Korea, and Helicobacter pylori (H. pylori) infection is also common. This study was performed to examine the association between H. pylori infection and gastric cancer, taking into account various other factors. To investigate the association between gastric adenocarcinoma and H. pylori infection, determined by urease-positive reaction in the CLO test, a total of 175 paired specimens (175 tumor and 175 tissues adjacent to tumor) of stomach cancer patients and a total of 113 control specimens were obtained. The positive H. pylori infection rates were 78.9% (138/175) among the patients in specimens of tumor or tissues adjacent to the tumor and 41.6% (47/113) among controls in the CLO test. A positive correlation between H. pylori infection and gastric cancer was observed (age-adjusted odds ratio, 7.0; MH chi2=34.5 with P<0.0005). These data suggest that stomach cancer patients in Korea have high infection rates of H. pylori regardless of site specificity, and this infection might be causally associated with stomach cancer.
胃腺癌是韩国最常见的癌症，幽门螺杆菌（H. pylori）感染也很普遍。本研究旨在考虑各种其他因素，探讨幽门螺杆菌感染与胃癌之间的关联。为了研究通过CLO试验中尿素酶阳性反应确定的胃腺癌与幽门螺杆菌感染之间的关联，共获得了175例胃癌患者的配对标本（175个肿瘤标本和175个肿瘤旁组织标本）以及113例对照标本。在肿瘤或肿瘤旁组织标本中，患者的幽门螺杆菌感染阳性率为78.9%（138/175），在CLO试验中对照组的感染阳性率为41.6%（47/113）。观察到幽门螺杆菌感染与胃癌之间存在正相关（年龄调整优势比为7.0；MH卡方=34.5，P<0.0005）。这些数据表明，韩国胃癌患者的幽门螺杆菌感染率较高，且与部位特异性无关，这种感染可能与胃癌存在因果关系。
Zotero 插件