人类胎儿端粒长度的同步性。

Synchrony in telomere length of the human fetus.

作者信息

Youngren K, Jeanclos E, Aviv H, Kimura M, Stock J, Hanna M, Skurnick J, Bardeguez A, Aviv A

机构信息

Division of Urology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103, USA.

出版信息

Hum Genet. 1998 Jun;102(6):640-3. doi: 10.1007/s004390050755.

DOI:10.1007/s004390050755

PMID:9703424

Abstract

Telomere length, measured by terminal restriction fragments, was examined in tissues from human fetuses of gestational ages estimated as 15-19 weeks. The length of telomeres was similar in most fetal tissues. However, there were significant variations in telomere length among fetuses, with no apparent relationship between gestational age and telomere length. We conclude that synchrony in telomere length exists among tissues of the human fetus. This synchrony is apparently lost during extrauterine life.

摘要

通过末端限制片段测量的端粒长度，在估计胎龄为15 - 19周的人类胎儿组织中进行了检测。大多数胎儿组织中的端粒长度相似。然而，胎儿之间的端粒长度存在显著差异，胎龄与端粒长度之间没有明显关系。我们得出结论，人类胎儿组织之间存在端粒长度同步性。这种同步性在宫外生活期间显然会丧失。