过氧化氢在5,6-亚苄基-L-抗坏血酸钠诱导抗肿瘤活性中的作用。
Role of hydrogen peroxide in antitumor activity induction by sodium 5,6-benzylidene-L-ascorbate.
作者信息
Sakagami H, Hosaka M, Arakawa H, Maeda M, Satoh K, Ida Y, Asano K, Hisamitsu T, Takimoto M, Ota H, Inagaki M, Sasuga K, Sho S, Tanaka T, Utsumi N, Oi T, Kochi M
机构信息
Department of Dental Pharmacology, Meikai University School of Dentistry, Saitama, Japan.
出版信息
Anticancer Res. 1998 Jul-Aug;18(4A):2519-24.
Role of hydrogen peroxide (H2O2) in the induction of antitumor activity against chemically-induced rat hepatocellular carcinoma by sodium 5,6-benzylidene-L-ascorbate (SBA) was investigated. ESR spectroscopy demonstrated that rat liver homogenate of cancerous tissue significantly enhanced the radical intensity of SBA more potently than that of precancerous or normal tissue. The peroxyoxalate chemiluminescence method demonstrated that SBA significantly enhanced the production of H2O2-derived chemiluminescence intensity in the liver homogenates, and the effect of SBA was greater in cancerous tissue than in precancerous or normal tissue. Addition of ascorbic acid, a degradation product of SBA, showed similar but slightly weaker stimulation effects. These data suggest that antitumor activity of SBA in vivo might, at least in part, be due to H2O2 production.
研究了过氧化氢（H₂O₂）在5,6-亚苄基-L-抗坏血酸钠（SBA）诱导抗化学诱导大鼠肝细胞癌的抗肿瘤活性中的作用。电子自旋共振光谱表明，癌组织的大鼠肝脏匀浆比癌前或正常组织更显著地增强了SBA的自由基强度。过氧草酸酯化学发光法表明，SBA显著增强了肝脏匀浆中H₂O₂衍生的化学发光强度，且SBA在癌组织中的作用比癌前或正常组织更大。添加SBA的降解产物抗坏血酸显示出相似但稍弱的刺激作用。这些数据表明，SBA在体内的抗肿瘤活性可能至少部分归因于H₂O₂的产生。
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