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人类和犬类球形细胞脑白质营养不良的形态学相似性。薄切片和冷冻断裂研究。

The morphologic similarities of human and canine globoid leukodystrophy. Thin section and freeze-fracture studies.

作者信息

Yunis E J, Lee R E

出版信息

Am J Pathol. 1976 Oct;85(1):99-114.

PMID:970445
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2032546/
Abstract

Human and canine globoid leukodystrophy are shown to be indistinguishable morphologically. Both have characteristic deposits with polygonal cross-sectional profiles in addition to twisted ribbon-like structures. The specificity of the deposits is emphasized, and their laminated nature is corroborated by the freeze-fracture studies. Their apparently hollow profiles in cross section are thought to be produced by the tight arrangement of the bilayers that prevent penetration of the stain.

摘要

人类和犬类球状细胞脑白质营养不良在形态学上表现出无法区分的特征。两者除了有扭曲的带状结构外，都有具有多边形横截面轮廓的特征性沉积物。沉积物的特异性得到强调，其分层性质通过冷冻断裂研究得到证实。它们在横截面中明显的中空轮廓被认为是由双层紧密排列阻止染色剂渗透而产生的。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9222/2032546/7b9ea772adef/amjpathol00443-0123-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9222/2032546/e747be99fb58/amjpathol00443-0124-a.jpg
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引用本文的文献

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本文引用的文献

1
Gaucher's disease. A morphologic study and measurements of iron metabolism.戈谢病。铁代谢的形态学研究与测量
Am J Med. 1967 Jun;42(6):891-8. doi: 10.1016/0002-9343(67)90070-8.
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Krabbe's disease (globoid leukodystrophy). Electron microscopic observations.
Arch Pathol. 1969 Sep;88(3):305-13.
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Krabbe's globoid cell leukodystrophy: deficiency of glactocerebrosidase in serum, leukocytes, and fibroblasts.克拉伯病（球状细胞脑白质营养不良症）：血清、白细胞和成纤维细胞中半乳糖脑苷脂酶缺乏。
Science. 1971 Jan 8;171(3966):73-5. doi: 10.1126/science.171.3966.73.
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Globoid cell leukodystrophy: specialized contact of globoid cell with astrocyte in the brain of twitcher mouse.球状细胞脑白质营养不良：颤抖小鼠大脑中球状细胞与星形胶质细胞的特殊接触。
Acta Neuropathol. 1982;58(4):237-42. doi: 10.1007/BF00688603.
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Characteristic inclusions in the kidney of canine globoid cell leukodystrophy.
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Sub-plasmalemmal linear density: a common structure in globoid cells and mesenchymal cells.亚浆膜线性密度：球样细胞和间充质细胞中的一种常见结构。
Acta Neuropathol. 1977 Aug 31;39(3):195-200. doi: 10.1007/BF00691697.
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Progress in investigations of sphingolipidoses.鞘脂类贮积病的研究进展
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Ultrastructural study of experimental globoid cells.实验性球状细胞的超微结构研究
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Tubules of globoid leukodystrophy: a right-handed helix.
Science. 1970 Jul 3;169(3940):64-6. doi: 10.1126/science.169.3940.64.
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Ultrastructure of globoid leukodystrophy (Krabbe's disease) with reference to the origin of globoid cells.
J Neuropathol Exp Neurol. 1970 Jul;29(3):441-62. doi: 10.1097/00005072-197007000-00008.
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Cytoplasmic inclusions in human globoid cell leukodystrophy. Krabbe's disease.人类球状细胞脑白质营养不良（克拉伯病）中的胞质内含物。
Arch Pathol. 1970 Jan;89(1):53-5.
8
Globoid cell leucodystrophy (Krabbe's disease): deficiency of galactocerebroside beta-galactosidase.球形细胞脑白质营养不良（克拉伯病）：半乳糖脑苷脂β-半乳糖苷酶缺乏症。
Proc Natl Acad Sci U S A. 1970 Jun;66(2):302-9. doi: 10.1073/pnas.66.2.302.
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Ultrastructural features of globoid-cell leukodystrophy in the dog.犬球状细胞脑白质营养不良的超微结构特征
Am J Vet Res. 1971 Jan;32(1):177-81.
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Freeze-etching and direct observation of freezing damage.
Cryobiology. 1969 Nov-Dec;6(3):137-50. doi: 10.1016/s0011-2240(69)80344-5.