CD34分子与造血祖细胞研究——临床医学中的一项挑战。

The CD34 molecule and hematopoietic progenitor cell studies--a challenge in clinical medicine.

作者信息

Egeland T

机构信息

Institute of Transplantation Immunology, Rikshospitalet, Oslo, Norway.

出版信息

Vox Sang. 1998;74 Suppl 2:467-8. doi: 10.1111/j.1423-0410.1998.tb05458.x.

DOI:10.1111/j.1423-0410.1998.tb05458.x

PMID:9704483

Abstract

The CD34 molecule, which is expressed at various levels on virtually all human hematopoietic progenitor cells (HPC), is a heavy glycosylated molecule with many different epitopes. A large series of CD34-specific monoclonal antibodies specific for different epitopes has been generated. Some of these antibodies do not react with particular HPC subpopulations. Thus, the antibodies used for HPC enumeration and isolation have to be carefully chosen with respect to what is aimed at.

摘要

CD34分子几乎在所有人类造血祖细胞（HPC）上均有不同程度的表达，它是一种具有许多不同表位的高度糖基化分子。现已产生了一系列针对不同表位的CD34特异性单克隆抗体。其中一些抗体不与特定的造血祖细胞亚群发生反应。因此，必须根据目标仔细选择用于造血祖细胞计数和分离的抗体。