Beckers J F, Zarrouk A, Batalha E S, Garbayo J M, Mester L, Szenci O
University of Liege, Faculty of Veterinary Medicine, Sart-Tilman, Belgium.
Acta Vet Hung. 1998;46(2):175-89.
The two main groups of placental proteins of ruminants are discussed in this paper: chorionic somatomammotropins (placental lactogens) and pregnancy-specific (-associated) proteins. Placental lactogens belong to the prolactin and growth hormone family. They stimulate mammogenesis, fetal growth and maternal metabolism. Pregnancy-specific proteins and pregnancy-associated glycoproteins belong to the aspartic proteinase family like pepsin, cathepsin D and E. These two groups of proteins are secreted in the maternal circulation by the binucleate cells after their migration to and fusion with the uterine cells. Their profiles were determined by radioimmunoassay (RIA). Further investigations are in progress to relate secretory profiles with alterations of the trophoblastic function such as those occurring in embryonic mortality, abortion, and fetal distress. The endocrine function of the primate and equine placenta is also discussed.
绒毛膜生长催乳素（胎盘催乳素）和妊娠特异性（相关）蛋白。胎盘催乳素属于催乳素和生长激素家族。它们刺激乳腺生成、胎儿生长和母体代谢。妊娠特异性蛋白和妊娠相关糖蛋白属于天冬氨酸蛋白酶家族，如胃蛋白酶、组织蛋白酶D和E。这两类蛋白在双核细胞迁移至子宫细胞并与之融合后，由双核细胞分泌到母体循环中。它们的水平通过放射免疫测定法（RIA）来确定。正在进行进一步研究，以将分泌水平与滋养层功能的改变联系起来，例如发生在胚胎死亡、流产和胎儿窘迫中的改变。本文还讨论了灵长类动物和马胎盘的内分泌功能。
