Podkletnova I, Alho H
Laboratory of Neurobiology, Medical School, University of Tampere, Finland.
J Chem Neuroanat. 1998 Jun;14(3-4):167-73. doi: 10.1016/s0891-0618(98)00006-4.
The influence of neonatal administration of 6-hydroxydopamine (6-OHDA) on the cell proliferation in cerebellum was studied using 10-30 days-old rats. Compared to their littermates, treated rats had poor ability in searching, skills performance and orienting in the new environment. Elimination of noradrenergic terminals by 6-OHDA led to a delay in granular cell migration. The secondary foliation in neo-cerebellum was absent. The Bergmann glial cells were abnormally located, structurally different and did not form the intimate association with Purkinje cells. Our findings indicate that without noradrenergic influence neurones and glial cells do not proliferate normally and noradrenaline may act as an important trophic factor also for Bergmann glial cells.
利用10至30日龄的大鼠，研究了新生期给予6-羟基多巴胺（6-OHDA）对小脑细胞增殖的影响。与同窝出生的大鼠相比，接受治疗的大鼠在新环境中的搜索、技能表现和定向能力较差。6-OHDA消除去甲肾上腺素能终末导致颗粒细胞迁移延迟。新小脑的次级叶形成缺失。伯格曼神经胶质细胞位置异常，结构不同，且未与浦肯野细胞形成紧密联系。我们的研究结果表明，在没有去甲肾上腺素能影响的情况下，神经元和神经胶质细胞不能正常增殖，去甲肾上腺素可能也是伯格曼神经胶质细胞的重要营养因子。
