Sengpiel F, Gödecke I, Stawinski P, Hübener M, Löwel S, Bonhoeffer T
Max-Planck-Institut für Neurobiologie, München-Martinsried, Germany.
Neuropharmacology. 1998 Apr-May;37(4-5):607-21. doi: 10.1016/s0028-3908(98)00034-3.
In the mammalian visual cortex, key neuronal response properties such as orientation preference and ocular dominance (OD) are mapped in an orderly fashion across the cortical surface. It has been known for some time that manipulating early postnatal visual experience can change the appearance of the OD map. Similar evidence for developmental plasticity of the orientation map has been scarce. We employed optical imaging of intrinsic signals to examine the contribution of intrinsic and environmental factors to the development of cortical maps, using the paradigms of strabismus, reverse occlusion and rearing in a single-orientation environment ('stripe-rearing'). For several weeks after induction of strabismus, the pattern of OD domains remained stable in young kittens. The isotropic magnification of the OD map matched the postnatal growth of the visual cortical surface during the same period. In reverse-occluded and in stripe-reared kittens, orientation preference maps obtained through the left and the right eye were very similar, although the two eyes had never shared any visual experience. We suggest that the geometry of functional maps in the visual cortex is intrinsically determined, while the relative strength of representation of different response properties can be modified through visual experience.
在哺乳动物的视觉皮层中，关键的神经元反应特性，如方向偏好和眼优势（OD），以有序的方式映射在整个皮层表面。一段时间以来，人们已经知道，操纵出生后的早期视觉经验可以改变OD图谱的外观。关于方向图谱发育可塑性的类似证据一直很少。我们采用内在信号的光学成像技术，利用斜视、反向遮盖和在单一方向环境中饲养（“条纹饲养”）等范式，研究内在因素和环境因素对皮层图谱发育的贡献。在诱发斜视后的几周内，幼猫的OD域模式保持稳定。OD图谱的各向同性放大与同期视觉皮层表面的出生后生长相匹配。在反向遮盖和条纹饲养的小猫中，通过左眼和右眼获得的方向偏好图谱非常相似，尽管两只眼睛从未共享过任何视觉经验。我们认为，视觉皮层中功能图谱的几何结构是由内在因素决定的，而不同反应特性的表征相对强度可以通过视觉经验进行修改。
