瘦素浓度无法预测体重增加：墨西哥城糖尿病研究。

Leptin concentrations do not predict weight gain: the Mexico City Diabetes Study.

作者信息

Haffner S M, Mykkänen L A, Gonzalez C C, Stern M P

机构信息

Department of Medicine, University of Texas Health Science Center at San Antonio, 78284-7873, USA.

出版信息

Int J Obes Relat Metab Disord. 1998 Jul;22(7):695-9. doi: 10.1038/sj.ijo.0800619.

DOI:10.1038/sj.ijo.0800619

PMID:9705032

Abstract

BACKGROUND

Leptin, a hormone which is produced by adipose tissue, has been shown to inhibit food intake and increase energy expenditure. In humans, leptin levels are correlated with body fat. In addition, leptin levels decline in subjects who lose weight. Yet few data exist on whether leptin levels predict weight change, except for a recent report suggesting that low leptin levels predict weight gain in very obese middle-aged Pima Indians.

METHODS

We have examined the association between baseline leptin levels and subsequent weight gain over 3.25 y in 180 non-diabetic participants in the Mexico City Diabetes Study.

RESULTS

At baseline, the correlation between leptin levels and body mass index (BMI) was 0.712 in men and 0.691 in women (both P < 0.001). Subjects were matched on age (+/- 2 y), gender and BMI (+/- 2 kg/m2) at baseline. Baseline BMI was 25.3 kg/m2 in men and 27.2 kg/m2 in women. Baseline leptin levels (ng/ml) did not predict weight gain in either men (weight gainers: 4.3; weight stable: 5.8; and weight losers: 5.2) or women (weight gainers: 17.4; weight stable: 17.7; and weight losers: 17.4).

CONCLUSIONS

We conclude that baseline leptin levels did not predict weight change in moderately obese individuals.

摘要

背景

瘦素是一种由脂肪组织产生的激素，已被证明可抑制食物摄入并增加能量消耗。在人类中，瘦素水平与体脂相关。此外，体重减轻的受试者瘦素水平会下降。然而，除了最近一份报告表明低瘦素水平可预测非常肥胖的中年皮马印第安人的体重增加外，关于瘦素水平是否能预测体重变化的数据很少。

方法

我们在墨西哥城糖尿病研究的180名非糖尿病参与者中，研究了基线瘦素水平与3.25年内随后体重增加之间的关联。

结果

在基线时，男性瘦素水平与体重指数（BMI）的相关性为0.712，女性为0.691（均P < 0.001）。受试者在基线时按年龄（±2岁）、性别和BMI（±2 kg/m²）进行匹配。男性基线BMI为25.3 kg/m²，女性为27.2 kg/m²。基线瘦素水平（ng/ml）在男性（体重增加者：4.3；体重稳定者：5.8；体重减轻者：5.2）或女性（体重增加者：17.4；体重稳定者：17.7；体重减轻者：17.4）中均不能预测体重增加。