Dunnick N R, Parker B R, Warnke R A, Castellino R A
AJR Am J Roentgenol. 1976 Oct;127(4):611-6. doi: 10.2214/ajr.127.4.611.
Twenty-six cases of histologically proven malignant histiocytosis are presented. Patient ages ranged from 20 months to 82 years, and a 10:3 male preponderance was seen. Clinical presentation is similar to that of malignant lymphoma and leukemia; histologic differentiation is required. The frequency of intrathoracic involvement at the time of presentation is similar to that of non-Hodgkin's lymphoma. Retroperitoneal lymph node invasion was readily seen on five of the eight lymphograms performed. Hepatosplenomegaly was a common finding, and three of the patients had evidence of bone involvement during the course of their illness. While there are no radiographic findings specific to malignant histiocytosis, the presence of hepatomegaly should suggest this possibility. The establishment of the correct diagnosis is important to guide choices in chemotherapy.
本文报告了26例经组织学证实的恶性组织细胞增多症病例。患者年龄从20个月至82岁不等，男性与女性比例为10:3。临床表现与恶性淋巴瘤和白血病相似；需要进行组织学鉴别。就诊时胸腔受累的频率与非霍奇金淋巴瘤相似。在进行的8例淋巴管造影中，有5例很容易发现腹膜后淋巴结侵犯。肝脾肿大是常见表现，3例患者在病程中出现骨受累证据。虽然没有特异性的恶性组织细胞增多症影像学表现，但肝肿大的存在应提示这种可能性。正确诊断的确立对于指导化疗方案的选择很重要。
