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本文引用的文献

1
The MCM2-3-5 proteins: are they replication licensing factors?MCM2 - 3 - 5蛋白：它们是复制许可因子吗？
Trends Cell Biol. 1994 May;4(5):160-6. doi: 10.1016/0962-8924(94)90200-3.
2
Multiple domains of fission yeast Cdc19p (MCM2) are required for its association with the core MCM complex.裂殖酵母Cdc19p（MCM2）的多个结构域是其与核心MCM复合物结合所必需的。
Mol Biol Cell. 1998 Jul;9(7):1833-45. doi: 10.1091/mbc.9.7.1833.
3
Biochemical function of mouse minichromosome maintenance 2 protein.小鼠微小染色体维持蛋白2的生化功能。
J Biol Chem. 1998 Apr 3;273(14):8369-75. doi: 10.1074/jbc.273.14.8369.
4
A globular complex formation by Nda1 and the other five members of the MCM protein family in fission yeast.裂殖酵母中Nda1与MCM蛋白家族的其他五个成员形成球状复合体。
Genes Cells. 1997 Jul;2(7):467-79. doi: 10.1046/j.1365-2443.1997.1350333.x.
5
A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.一种DNA解旋酶活性与MCM4、MCM6和MCM7蛋白复合体相关。
J Biol Chem. 1997 Sep 26;272(39):24508-13. doi: 10.1074/jbc.272.39.24508.
6
Expression, nuclear localization and interactions of human MCM/P1 proteins.人类MCM/P1蛋白的表达、核定位及相互作用
Biochem Biophys Res Commun. 1997 Jul 9;236(1):118-25. doi: 10.1006/bbrc.1997.6865.
7
Licensing of DNA replication by a multi-protein complex of MCM/P1 proteins in Xenopus eggs.非洲爪蟾卵中由MCM/P1蛋白多蛋白复合体对DNA复制的许可。
EMBO J. 1997 Jun 2;16(11):3320-31. doi: 10.1093/emboj/16.11.3320.
8
The RLF-M component of the replication licensing system forms complexes containing all six MCM/P1 polypeptides.复制许可系统的RLF-M组件形成包含所有六种MCM/P1多肽的复合物。
EMBO J. 1997 Jun 2;16(11):3312-9. doi: 10.1093/emboj/16.11.3312.
9
Chromatin proteins involved in the initiation of DNA replication.参与DNA复制起始的染色质蛋白。
Curr Opin Genet Dev. 1997 Apr;7(2):152-7. doi: 10.1016/s0959-437x(97)80123-2.
10
In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP.人MCM异源六聚体复合物与染色质的体内相互作用。ATP的可能参与。
J Biol Chem. 1997 Apr 18;272(16):10928-35. doi: 10.1074/jbc.272.16.10928.

粟酒裂殖酵母Mcm3p是一种必需的核蛋白，与Nda4p（Mcm5p）紧密结合。

Schizosaccharomyces pombe Mcm3p, an essential nuclear protein, associates tightly with Nda4p (Mcm5p).

作者信息

Sherman D A, Forsburg S L

机构信息

Molecular Biology and Virology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla,CA 92037, USA.

出版信息

Nucleic Acids Res. 1998 Sep 1;26(17):3955-60. doi: 10.1093/nar/26.17.3955.

DOI:10.1093/nar/26.17.3955
PMID:9705504
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC147805/
Abstract

MCM proteins are required for the proper regulation of DNA replication. There are six MCM proteins in all eukaryotes which interact to form a large complex. We report the cloning of fission yeast mcm3 +. mcm3 + is essential and spores carrying a Delta mcm3 disruption arrest with an apparently replicated DNA content. The protein is found constitutively in the nucleus and levels remain constant throughout the cell cycle. Mcm3p binds particularly tightly to Nda4p (Mcm5p), but is loosely associated with the other Schizosaccharomyces pombe MCM proteins. Thus, Mcm3p is a peripheral MCM subunit.

摘要

MCM蛋白是DNA复制正常调控所必需的。所有真核生物中都有六种MCM蛋白，它们相互作用形成一个大型复合体。我们报道了裂殖酵母mcm3 +的克隆。mcm3 +是必需的，携带Δmcm3缺失的孢子会因DNA含量明显复制而停滞。该蛋白在细胞核中持续存在，且在整个细胞周期中水平保持恒定。Mcm3p与Nda4p（Mcm5p）结合特别紧密，但与其他粟酒裂殖酵母MCM蛋白结合松散。因此，Mcm3p是一种外周MCM亚基。