Gaszynski W, Jezewska D, Kanski A
Anaesth Resusc Intensive Ther. 1976 Jan-Mar;4(1):47-51.
The effect of ketamine administered to 20 rabbits in a single dose and in fractionated doses on the blood clotting system was studied. The following blood clotting indices were determined: thrombelastography (TEG), plasma thrombin time, platelet count, euglobulin lysis time. No statistically significant differences were observed in the activity of clotting and fibrinolysis systems in the group of animals receiving a single dose of ketamine and in the group receiving fractionated doses. The obtained results suggest that ketamine as an agent used for dissociative anaesthesia can be administered safely in serious conditions associated with disturbances in the haemostasis system.
研究了单次给药和分次给药的氯胺酮对20只兔子血液凝固系统的影响。测定了以下血液凝固指标：血栓弹力图（TEG）、血浆凝血酶时间、血小板计数、优球蛋白溶解时间。在接受单次氯胺酮剂量的动物组和接受分次剂量的动物组中，凝血和纤溶系统的活性未观察到统计学上的显著差异。所得结果表明，氯胺酮作为一种用于分离麻醉的药物，可以在与止血系统紊乱相关的严重情况下安全给药。
