Gaszyński W, Majka A
Anaesth Resusc Intensive Ther. 1976 Apr-Jun;4(2):79-84.
The effect of ketamine on the activity of lysosomal enzymes in peripheral blood granulocytes was studied in guinea pigs. Ketamine was given intramuscularly in one single dose, in divided doses and in long-term administration (repeatedly) for 14 days. The blood for determination was obtained from the heart, the lysosomes were prepared by the Chodirker's method determining the activity of marker enzymes: acid phosphatase, acid protease and neutral protease, in the obtained fractions. No statistically significant differences were found in the activity of lysosomal enzymes in the studied groups. The results obtained point out the usefulness of ketamine in severe conditions associated with significant catabolic changes in the organism.
在豚鼠身上研究了氯胺酮对其外周血粒细胞溶酶体酶活性的影响。氯胺酮通过单次肌肉注射、分次肌肉注射以及长期（重复）给药14天的方式给予。用于检测的血液取自心脏，通过乔迪尔克（Chodirker）方法制备溶酶体，在所获得的组分中检测标记酶——酸性磷酸酶、酸性蛋白酶和中性蛋白酶的活性。在所研究的各组中，未发现溶酶体酶活性有统计学上的显著差异。所获得的结果表明氯胺酮在与机体显著分解代谢变化相关的严重病症中具有应用价值。
