Kmonícková E, Nováková O, Tvrzická E, Mráz M, Hynie S
Institute of Pharmacology, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Physiol Res. 1998;47(2):109-14.
The content of phospholipids and their fatty acid composition were followed in the hearts of two inbred strains of rats: IR, resistant against the development of isoprenaline-induced myocardial lesions and IS, sensitive to their development. In the hearts of rats of the resistant strain, a lower content of phosphatidylcholine and its plasmalogen fraction was found compared to IS rats. The total amount of phospholipids was only insignificantly lower in IR rats. Greater differences were found in individual fatty acids. The most important finding concerned lower arachidonic acid and higher linoleic acid content in heart phospholipids of IR rats. These differences were exactly opposite to changes reported in the literature in animals known to have a higher resistance against myocardial damage due to various interventions. Our results do not support the hypothesis claiming the importance of changes in phospholipids and their FA composition for the resistance of the heart against the development of necrotic lesions.
IR系大鼠对异丙肾上腺素诱导的心肌损伤具有抗性，IS系大鼠对该损伤敏感。与IS系大鼠相比，抗性系大鼠心脏中磷脂酰胆碱及其缩醛磷脂部分的含量较低。IR系大鼠中磷脂的总量仅略有降低。在单个脂肪酸方面发现了更大的差异。最重要的发现是，IR系大鼠心脏磷脂中花生四烯酸含量较低，亚油酸含量较高。这些差异与文献中报道的因各种干预而对心肌损伤具有较高抗性的动物的变化正好相反。我们的结果不支持认为磷脂及其脂肪酸组成的变化对心脏抵抗坏死性病变发展具有重要性的假说。
