Ristić V, Tepsić V, De Luka S R, Vrbaski S R
Institute for Medical Research, Belgrade, Yugoslavia.
Physiol Res. 1998;47(2):115-8.
The effects of chronic diazepam treatment (10 mg/kg/day for 180 days) on the fractional distribution and fatty acid composition of heart phospholipids were studied in male Wistar rats. It was found that diazepam treatment increased the content of phosphatidylcholine and cardiolipin in the heart and slightly increased its phosphatidylcholine fraction. There were no significant changes in fatty acid composition after diazepam treatment in heart phospholipids, with the exception of significant decrease of 20:3n-6 and 20:5n-3 fatty acids. Our findings suggest that diazepam, probably through peripheral benzodiazepine binding sites, altered the content of heart cardiolipin and caused changes in the flux of oxidative phosphorylation in the heart.
研究了慢性地西泮治疗（10毫克/千克/天，持续180天）对雄性Wistar大鼠心脏磷脂的分数分布和脂肪酸组成的影响。发现地西泮治疗增加了心脏中磷脂酰胆碱和心磷脂的含量，并使其磷脂酰胆碱分数略有增加。地西泮治疗后，心脏磷脂的脂肪酸组成没有显著变化，但20:3n-6和20:5n-3脂肪酸显著减少除外。我们的研究结果表明，地西泮可能通过外周苯二氮䓬结合位点，改变了心脏心磷脂的含量，并导致心脏氧化磷酸化通量的变化。
