Rholl J C, Yavorski R T, Cheney C P, Wong R K
Department of Gastroenterology, Walter Reed Army Medical Center, Washington, DC 20307-5001, USA.
Am J Gastroenterol. 1998 Aug;93(8):1381-3. doi: 10.1111/j.1572-0241.1998.428_i.x.
Esophagogastric fistula formation as a complication of esophageal Crohn's has been reported in only one case in the literature. In addition, only eight cases of esophageal fistulae of any type have been reported in the setting of Crohn's disease. Unlike the more often described superficial, aphthous disease of the esophagus, response of fistulae to medical therapy has been disappointing, and recurrence and progression are likely. Surgery remains the primary modality for refractory disease. The roles of salicylates, antibiotics, immunosuppressive agents, sealants, and intralesional steroid injections have not been well defined. We present a case of severe, refractory Crohn's disease with fistula formation between the esophagus and stomach, and concomitant involvement of the oropharynx, duodenum, terminal ileum, and cecum.
食管胃瘘形成作为食管克罗恩病的一种并发症，文献中仅报道过1例。此外，在克罗恩病背景下，仅报道过8例任何类型的食管瘘。与更常描述的食管浅表性阿弗他病不同，瘘对药物治疗的反应令人失望，且可能复发和进展。手术仍然是难治性疾病的主要治疗方式。水杨酸盐、抗生素、免疫抑制剂、封闭剂和病灶内注射类固醇的作用尚未明确界定。我们报告1例严重难治性克罗恩病患者，该患者食管与胃之间形成瘘，并伴有口咽、十二指肠、回肠末端和盲肠受累。
