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1
Promoter-proximal stalling results from the inability to recruit transcription factor IIH to the transcription complex and is a regulated event.启动子近端停滞是由于无法将转录因子IIH招募到转录复合物中所致，是一个受调控的事件。
Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9767-72. doi: 10.1073/pnas.95.17.9767.
2
A role for the TFIIH XPB DNA helicase in promoter escape by RNA polymerase II.TFIIH XPB DNA解旋酶在RNA聚合酶II启动子逃逸中的作用。
J Biol Chem. 1999 Aug 6;274(32):22127-30. doi: 10.1074/jbc.274.32.22127.
3
Promoter escape limits the rate of RNA polymerase II transcription and is enhanced by TFIIE, TFIIH, and ATP on negatively supercoiled DNA.启动子逃逸限制了RNA聚合酶II的转录速率，并且在负超螺旋DNA上，TFIIE、TFIIH和ATP可增强启动子逃逸。
Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9232-7. doi: 10.1073/pnas.95.16.9232.
4
Promoter escape by RNA polymerase II. Formation of an escape-competent transcriptional intermediate is a prerequisite for exit of polymerase from the promoter.RNA聚合酶II的启动子逃逸。形成具备逃逸能力的转录中间体是聚合酶从启动子处离开的前提条件。
J Biol Chem. 1997 Nov 7;272(45):28175-8. doi: 10.1074/jbc.272.45.28175.
5
Mechanism of ATP-dependent promoter melting by transcription factor IIH.转录因子IIH介导的ATP依赖型启动子解链机制
Science. 2000 May 26;288(5470):1418-22. doi: 10.1126/science.288.5470.1418.
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Transcription factors IIE and IIH and ATP hydrolysis direct promoter clearance by RNA polymerase II.转录因子IIE和IIH以及ATP水解引导RNA聚合酶II清除启动子。
Cell. 1994 Apr 8;77(1):145-56. doi: 10.1016/0092-8674(94)90242-9.
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Reconstitution of recombinant TFIIH that can mediate activator-dependent transcription.可介导激活剂依赖性转录的重组TFIIH的重组。
Genes Cells. 2001 Aug;6(8):707-19. doi: 10.1046/j.1365-2443.2001.00456.x.
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Dual roles for transcription factor IIF in promoter escape by RNA polymerase II.转录因子IIF在RNA聚合酶II的启动子逃逸过程中的双重作用。
J Biol Chem. 1999 Dec 10;274(50):35668-75. doi: 10.1074/jbc.274.50.35668.
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Promoter escape by RNA polymerase II. A role for an ATP cofactor in suppression of arrest by polymerase at promoter-proximal sites.RNA聚合酶II的启动子逃逸。一种ATP辅因子在抑制聚合酶在启动子近端位点停滞中的作用。
J Biol Chem. 1996 Sep 20;271(38):23352-6. doi: 10.1074/jbc.271.38.23352.
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TFIIH action in transcription initiation and promoter escape requires distinct regions of downstream promoter DNA.转录起始和启动子逃逸过程中TFIIH的作用需要下游启动子DNA的不同区域。
Proc Natl Acad Sci U S A. 2001 May 8;98(10):5544-9. doi: 10.1073/pnas.101004498. Epub 2001 May 1.
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New Insights into HIV Life Cycle, Th1/Th2 Shift during HIV Infection and Preferential Virus Infection of Th2 Cells: Implications of Early HIV Treatment Initiation and Care.对HIV生命周期、HIV感染期间Th1/Th2偏移及Th2细胞的优先病毒感染的新见解：早期启动HIV治疗与护理的意义
Life (Basel). 2024 Jan 9;14(1):104. doi: 10.3390/life14010104.
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Nucleotide excision repair: a versatile and smart toolkit.核苷酸切除修复：一种通用且智能的工具包。
Acta Biochim Biophys Sin (Shanghai). 2022 May 25;54(6):807-819. doi: 10.3724/abbs.2022054.
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Human Immunodeficiency Virus Type-1 (HIV-1) Transcriptional Regulation, Latency and Therapy in the Central Nervous System.1型人类免疫缺陷病毒（HIV-1）在中枢神经系统中的转录调控、潜伏及治疗
Vaccines (Basel). 2021 Nov 3;9(11):1272. doi: 10.3390/vaccines9111272.
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AP-1 and NF-κB synergize to transcriptionally activate latent HIV upon T-cell receptor activation.在T细胞受体激活后，AP-1和NF-κB协同作用，转录激活潜伏的HIV。
FEBS Lett. 2021 Mar;595(5):577-594. doi: 10.1002/1873-3468.14033. Epub 2021 Feb 9.
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Efficient Non-Epigenetic Activation of HIV Latency through the T-Cell Receptor Signalosome.通过 T 细胞受体信号复合物高效非表观遗传激活 HIV 潜伏。
Viruses. 2020 Aug 8;12(8):868. doi: 10.3390/v12080868.
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Structure and mechanism of the RNA polymerase II transcription machinery.RNA 聚合酶 II 转录机制的结构与机制。
Genes Dev. 2020 Apr 1;34(7-8):465-488. doi: 10.1101/gad.335679.119.
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TFIIB is only ∼9 Å away from the 5'-end of a trimeric RNA primer in a functional RNA polymerase II preinitiation complex.在功能性RNA聚合酶II起始前复合物中，TFIIB与三聚体RNA引物的5'端仅相距约9埃。
PLoS One. 2015 Mar 16;10(3):e0119007. doi: 10.1371/journal.pone.0119007. eCollection 2015.
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Erk1/2 activity promotes chromatin features and RNAPII phosphorylation at developmental promoters in mouse ESCs.ERK1/2 活性促进了胚胎干细胞发育启动子处的染色质特征和 RNA 聚合酶 II 磷酸化。
Cell. 2014 Feb 13;156(4):678-90. doi: 10.1016/j.cell.2014.01.009.
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Arabidopsis IWS1 interacts with transcription factor BES1 and is involved in plant steroid hormone brassinosteroid regulated gene expression.拟南芥 IWS1 与转录因子 BES1 相互作用，参与植物甾体激素油菜素内酯调控的基因表达。
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3918-23. doi: 10.1073/pnas.0909198107. Epub 2010 Feb 5.
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A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint.Chk1在S期检查点阻断p21 RNA转录延伸过程中的作用。
Genes Dev. 2009 Jun 1;23(11):1364-77. doi: 10.1101/gad.1795709.
本文引用的文献
1
Three transitions in the RNA polymerase II transcription complex during initiation.起始过程中RNA聚合酶II转录复合物的三个转变。
EMBO J. 1997 Dec 15;16(24):7468-80. doi: 10.1093/emboj/16.24.7468.
2
Recruitment of the putative transcription-repair coupling factor CSB/ERCC6 to RNA polymerase II elongation complexes.将假定的转录修复偶联因子CSB/ERCC6招募至RNA聚合酶II延伸复合物。
Mol Cell Biol. 1997 Dec;17(12):6803-14. doi: 10.1128/MCB.17.12.6803.
3
Promoter escape by RNA polymerase II. Formation of an escape-competent transcriptional intermediate is a prerequisite for exit of polymerase from the promoter.RNA聚合酶II的启动子逃逸。形成具备逃逸能力的转录中间体是聚合酶从启动子处离开的前提条件。
J Biol Chem. 1997 Nov 7;272(45):28175-8. doi: 10.1074/jbc.272.45.28175.
4
Genetic analysis of the large subunit of yeast transcription factor IIE reveals two regions with distinct functions.酵母转录因子IIE大亚基的遗传分析揭示了两个具有不同功能的区域。
Mol Cell Biol. 1997 Sep;17(9):5288-98. doi: 10.1128/MCB.17.9.5288.
5
A role for TFIIH in controlling the activity of early RNA polymerase II elongation complexes.TFIIH在控制早期RNA聚合酶II延伸复合物活性中的作用。
Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9006-10. doi: 10.1073/pnas.94.17.9006.
6
The general transcription factors of RNA polymerase II.RNA聚合酶II的通用转录因子。
Genes Dev. 1996 Nov 1;10(21):2657-83. doi: 10.1101/gad.10.21.2657.
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Purification of human RNA polymerase II and general transcription factors.人RNA聚合酶II和通用转录因子的纯化。
Methods Enzymol. 1996;274:72-100. doi: 10.1016/s0076-6879(96)74009-0.
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Distinct activated and non-activated RNA polymerase II complexes in yeast.酵母中不同的激活态和非激活态RNA聚合酶II复合物
EMBO J. 1996 Sep 2;15(17):4654-64.
9
The multiple roles of transcription/repair factor TFIIH.转录/修复因子TFIIH的多重作用。
Trends Biochem Sci. 1996 Sep;21(9):346-50.
10
DNA excision repair.DNA切除修复
Annu Rev Biochem. 1996;65:43-81. doi: 10.1146/annurev.bi.65.070196.000355.
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