Ipp M M, Howard N J, Tervo R C, Gelfand E W
Ann Intern Med. 1976 Oct;85(4):443-6. doi: 10.7326/0003-4819-85-4-443.
A 15-year-old girl is described with the sicca syndrome of keratoconjunctivitis and xerostomia. There was no associated rheumatoid arthritis or other connective tissue disorder, but total lipodystrophy had been present since the age of 9 years. Marked hyperreactivity of the humoral immune system and suppression of cell-mediated immunity was shown. The association of sicca syndrome with total lipodystrophy has not previously been reported.
一名15岁女孩被诊断患有角膜结膜炎和口腔干燥的干燥综合征。她没有相关的类风湿性关节炎或其他结缔组织疾病，但自9岁起就出现了全身脂肪营养不良。结果显示其体液免疫系统存在明显的高反应性，而细胞介导的免疫受到抑制。干燥综合征与全身脂肪营养不良的关联此前尚未见报道。
