Altomonte L, Zoli A, Galossi A, Mirone L, Scuderi F, Magarò M
Istituto di Medicina Interna e Geriatria, Università Cattolica del Sacro Cuore di Roma.
Ann Ital Med Int. 1995 Apr-Jun;10(2):103-6.
In order to evaluate the autoantibody pattern of subjects affected by rheumatoid arthritis (RA) with clinical features of keratoconjunctivitis, we studied 32 out- and in-patients (26 women, 6 men, average age 52 years, average disease duration 5.5 years) at the Division of Rheumatology, Catholic University of Rome. We found keratoconjunctivitis sicca and xerostomia in 22 (68.75%) patients with RA. Rheumatoid factor was present in 17 (53.1%) patients, antinuclear antibodies (ANA) were observed in 15 (48.4%) patients, and anti-rheumatoid arthritis nuclear antigens (RANA) in 22 (68.7%) patients; anti-SSA antibodies were confirmed in 3 (9.4%) patients and anti-SSB antibodies in 2 (6.2%) patients. None of the patients evidenced anti-U1RNP. Although keratoconjunctivitis sicca and xerostomia correlated significantly with the presence of rheumatoid factor, we found no relationship between these two conditions and ANA or anti-RANA antibodies. The high frequency of keratoconjunctivitis sicca and xerostomia in our RA patients is the expression of extra-articular involvement in this disease and is correlated with the presence of rheumatoid factor. ANA and anti-RANA antibodies may represent aspecific polyclonal activation in RA.
为了评估具有角结膜炎临床特征的类风湿关节炎（RA）患者的自身抗体模式，我们研究了罗马天主教大学风湿病科的32名门诊和住院患者（26名女性，6名男性，平均年龄52岁，平均病程5.5年）。我们在22名（68.75%）RA患者中发现了干燥性角结膜炎和口干症。17名（53.1%）患者存在类风湿因子，15名（48.4%）患者观察到抗核抗体（ANA），22名（68.7%）患者存在抗类风湿关节炎核抗原（RANA）；3名（9.4%）患者确诊有抗SSA抗体，2名（6.2%）患者有抗SSB抗体。没有患者检测到抗U1RNP。虽然干燥性角结膜炎和口干症与类风湿因子的存在显著相关，但我们发现这两种情况与ANA或抗RANA抗体之间没有关系。我们的RA患者中干燥性角结膜炎和口干症的高发生率是该疾病关节外受累的表现，并且与类风湿因子的存在相关。ANA和抗RANA抗体可能代表RA中的非特异性多克隆激活。
