Mizuno Y, Hara T, Hatae K, Hirano T, Ueda K, Nakamura N, Mizoguchi Y
Department of Paediatrics, Faculty of Medicine, Kyushu University, Fukuoka City, Japan.
Eur J Pediatr. 1989 Feb;148(5):414-6. doi: 10.1007/BF00595900.
Recurrent parotid gland enlargement is a common disorder in children, while that of auto-immune aetiology is rare. Three children with recurrent parotid swelling had autoantibodies including antinuclear antibody, anti-SS-A (Sjögren syndrome-A), SS-B (Sjögren syndrome-B) antibodies and rheumatoid factor, abnormal sialograms and lymphocytic infiltration of salivary glands, which were consistent with Sjögren syndrome. Initially, all three lacked symptoms of keratoconjunctivitis sicca. During follow up, two patients developed xerostomia and were diagnosed as having primary Sjögren syndrome. Recurrent parotid enlargement appears to be important as an initial manifestation of Sjögren syndrome in children.
复发性腮腺肿大是儿童常见疾病，而自身免疫性病因导致的复发性腮腺肿大则较为罕见。三名复发性腮腺肿大患儿存在自身抗体，包括抗核抗体、抗SS - A（干燥综合征A）、SS - B（干燥综合征B）抗体及类风湿因子，唾液腺造影异常且唾液腺有淋巴细胞浸润，这些均符合干燥综合征表现。起初，这三名患儿均无干燥性角结膜炎症状。随访期间，两名患者出现口干症状，并被诊断为原发性干燥综合征。复发性腮腺肿大似乎是儿童干燥综合征的重要首发表现。
