一种合成新型环烷环稠合吡啶核苷作为潜在抗HIV药物的策略。
A synthetic strategy to a new class of cycloalkane ring-fused pyridine nucleosides as potential anti HIV agents.
作者信息
Elgemeie G E, Attia A M, Hussain B A
机构信息
Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt.
出版信息
Nucleosides Nucleotides. 1998 May;17(5):855-68. doi: 10.1080/07328319808003458.
PMID:9708328
Abstract
Condensation of cyanothioacetamide or cyanoacetamide with sodium salts of 2-formyl-1-cycloalkanones afforded the corresponding cycloalkane ring fused pyridine-2(1H)-thiones and -2-pyridones. The latter compounds served as a key intermediates for the synthesis of a new class of cycloalkane ring fused pyridine glycosides.
摘要
氰硫基乙酰胺或氰基乙酰胺与2-甲酰基-1-环烷酮的钠盐缩合，得到相应的稠合于环烷烃环的吡啶-2(1H)-硫酮和-2-吡啶酮。后一类化合物是合成一类新型稠合于环烷烃环的吡啶糖苷的关键中间体。
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