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7价肺炎球菌结合疫苗联合23价肺炎球菌疫苗在镰状细胞病儿童和青年中的接种方案。

Combined schedule of 7-valent pneumococcal conjugate vaccine followed by 23-valent pneumococcal vaccine in children and young adults with sickle cell disease.

作者信息

Vernacchio L, Neufeld E J, MacDonald K, Kurth S, Murakami S, Hohne C, King M, Molrine D

机构信息

Laboratory of Infectious Diseases, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

出版信息

J Pediatr. 1998 Aug;133(2):275-8. doi: 10.1016/s0022-3476(98)70235-5.

DOI:10.1016/s0022-3476(98)70235-5
PMID:9709721
Abstract

We compared the immunogenicity of 7-valent pneumococcal-conjugate vaccine plus 23-valent pneumococcal vaccine to immunization with 23-valent vaccine only in individuals > or = 2 years of age with sickle cell disease. IgG pneumococcal antibody concentrations were higher in the combined schedule group with no increase in side effects observed after immunization with 23-valent vaccine.

摘要

我们比较了7价肺炎球菌结合疫苗加23价肺炎球菌疫苗与仅接种23价疫苗在2岁及以上镰状细胞病患者中的免疫原性。联合接种组的IgG肺炎球菌抗体浓度更高，接种23价疫苗后未观察到副作用增加。

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