Kaplan J, Sarnaik S, Schiffman G
Am J Pediatr Hematol Oncol. 1986 Spring;8(1):80-2.
To determine if revaccination improves levels of antibodies to pneumococcal polysaccharide types 6A, 14, and 19, 86 subjects with sickle cell anemia between 4 and 23 years old were given a booster injection of a polyvalent pneumococcal vaccine 37 to 53 months after primary immunization. Most subjects had mild local reactions similar to those seen after primary immunization. Only two subjects, both young adults, had severe local and systemic reactions. The percentages of subjects with protective antibody levels to types 6A, 14, and 19 increased from 74%, 44%, and 79% respectively before boosting, to 92%, 66%, and 92% respectively after boosting. Revaccination of children and young adults with sickle cell anemia appears to result in increased protective levels of antibody, and is associated with a low prevalence of severe reactions.
为了确定再次接种疫苗是否能提高针对肺炎球菌6A、14和19型多糖的抗体水平，对86名4至23岁的镰状细胞贫血患者在初次免疫37至53个月后给予一剂多价肺炎球菌疫苗加强针。大多数受试者出现了与初次免疫后相似的轻度局部反应。只有两名年轻成年人出现了严重的局部和全身反应。针对6A、14和19型具有保护性抗体水平的受试者百分比分别从加强前的74%、44%和79%，升至加强后的92%、66%和92%。对患有镰状细胞贫血的儿童和年轻成年人再次接种疫苗似乎会提高抗体的保护水平，且严重反应的发生率较低。
