不明原因持续性天门冬氨酸氨基转移酶升高儿童的巨酶研究与监测

Macroenzyme investigation and monitoring in children with persistent increase of aspartate aminotransferase of unexplained origin.

作者信息

Fortunato G, Iorio R, Esposito P, Lofrano M M, Vegnente A, Vajro P

机构信息

Department of Biochemistry and Medical Biotechnology, Medical School, University of Naples Federico II, Italy.

出版信息

J Pediatr. 1998 Aug;133(2):286-9. doi: 10.1016/s0022-3476(98)70238-0.

DOI:10.1016/s0022-3476(98)70238-0

PMID:9709724

Abstract

Ten children with asymptomatic persistent cryptogenic increased serum levels of aspartate aminotransferase (AST) were screened for detection and monitoring of AST macroenzyme (macroAST). MacroAST was found in 4 patients; their serum AST levels were significantly higher than in those without biochemical evidence of macroAST (mean +/- SD: 515 +/- 433 and 78 +/- 16 IU/L, respectively; P = .0095). MacroAST was a persistent, benign phenomenon and was probably not congenital.

摘要

对10名无症状持续性不明原因血清天冬氨酸氨基转移酶（AST）水平升高的儿童进行筛查，以检测和监测AST巨酶（macroAST）。在4名患者中发现了macroAST；他们的血清AST水平显著高于没有macroAST生化证据的患者（分别为均值±标准差：515±433和78±16 IU/L；P = 0.0095）。MacroAST是一种持续性的良性现象，可能并非先天性的。