Fortunato G, Iorio R, Esposito P, Lofrano M M, Vegnente A, Vajro P
Department of Biochemistry and Medical Biotechnology, Medical School, University of Naples Federico II, Italy.
J Pediatr. 1998 Aug;133(2):286-9. doi: 10.1016/s0022-3476(98)70238-0.
Ten children with asymptomatic persistent cryptogenic increased serum levels of aspartate aminotransferase (AST) were screened for detection and monitoring of AST macroenzyme (macroAST). MacroAST was found in 4 patients; their serum AST levels were significantly higher than in those without biochemical evidence of macroAST (mean +/- SD: 515 +/- 433 and 78 +/- 16 IU/L, respectively; P = .0095). MacroAST was a persistent, benign phenomenon and was probably not congenital.
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