Wenzel R P, Edmond M B
Department of Internal Medicine, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond 23298-0663, USA.
Clin Infect Dis. 1998 Aug;27(2):245-9; quiz 250-1. doi: 10.1086/514646.
The lessons of the antibiotic era are crystal clear: in the footrace between humans and microbes, the organisms' genetic repertoire and efficient response to environmental changes will win the day. New antibiotics are essential, but their shelf life will be enhanced only if used wisely and sparingly. The antibiotic era is continually threatened by inappropriate decisions regarding use, inappropriate choices, and unnecessary durations of treatment. In concert with improved prescribing habits, efforts to identify and isolate resistant organisms introduced from outside institutions are essential. Last, continual energy is needed to influence the behavior of health care professionals and to maintain optimal infection control policies and procedures. We remain optimistic about the ability of infectious diseases physicians to respond appropriately to continued microbial challenges with research, education, and wise practice.
在人类与微生物的竞赛中，微生物的基因库及其对环境变化的高效反应将最终取胜。新型抗生素至关重要，但只有明智且谨慎地使用，其有效期才会延长。抗生素时代不断受到用药决策不当、选择不当以及治疗疗程不必要等问题的威胁。与改善处方习惯相结合，识别和隔离外部机构引入的耐药菌的努力至关重要。最后，需要持续投入精力来影响医护人员的行为，并维持最佳的感染控制政策和程序。我们对传染病医生通过研究、教育和明智的实践来妥善应对持续的微生物挑战的能力仍持乐观态度。
