酶诱导对泼尼松龙代谢的影响。临床与实验室研究。
Effects of enzyme induction on metabolism of prednisolone. Clinical and laboratory study.
作者信息
Brooks P M, Buchanan W W, Grove M, Downie W W
出版信息
Ann Rheum Dis. 1976 Aug;35(4):339-43. doi: 10.1136/ard.35.4.339.
Abstract
The addition of phenobarbitone in therapeutic dosage to the drug regimen of prednisolone-treated subjects with rheumatoid arthritis produced measurable deterioration in the clinical status of the patients associated with a more rapid clearance of prednisolone from plasma. It is considered that phenobarbitone induced the hepatic metabolism of prednisolone, effectively reducing the steady state plasma level and resulting in clinical relapse. A slight but significant improvement in the adrenocortical response to tetracosactrin (Synacthen) was noted after phenobarbitone therapy.
摘要
对于接受泼尼松龙治疗的类风湿性关节炎患者，在其药物治疗方案中添加治疗剂量的苯巴比妥后，患者的临床状况出现了可测量的恶化，同时泼尼松龙从血浆中的清除速度加快。据认为，苯巴比妥诱导了泼尼松龙的肝脏代谢，有效降低了稳态血浆水平，导致临床复发。苯巴比妥治疗后，观察到肾上腺皮质对二十四肽促皮质素（合成促皮质素）的反应略有但显著改善。
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