Venkatraman J T, Pendergast D
Nutrition Program, State University of New York at Buffalo 14214, USA
Med Sci Sports Exerc. 1998 Aug;30(8):1198-204. doi: 10.1097/00005768-199808000-00003.
Chronic exercise and high fat diets have been associated with immune suppression. We have reported the effects of level of dietary fat and exercise on lymphocyte subsets, proliferative response, and in vitro production of cytokines by peripheral blood mononuclear cells of runners. The present study was planned to further investigate whether the mechanisms of action of dietary fats is through their modulation of plasma cytokines in runners.
This study compared plasma cytokines at rest and after endurance exercise at 80% of V02max in female (N = 8-10) and male (N = 8-10) runners after eating diets comprised of 17% (LF), 32% (MF), and 41% (HF) fats (4 wk each).
The level of interleukin-1 beta (IL-1 beta) was independent of gender, exercise, and level of dietary fat. tumor necrosis factor (TNF-alpha) level was higher in the plasma of men compared with that in women runners, and the level of these two cytokines increased with increasing level of dietary fat. Plasma interleukin-2 (IL-2) level (a cytokine involved in enhancing T cell functions for host defense) was significantly higher in men compared with that in women runners and decreased in men with increase dietary fat. Plasma interleukin-6(IL-6) level was significantly lower after the endurance run, and IL-6 levels decreased with increase in dietary fat.
Data from the present study suggest that dietary fat has differential effects on plasma cytokine levels in runners. Increasing the level of dietary fat significantly increased endurance run time and had no adverse effects on the level of plasma IL-2 and pro-inflammatory cytokines (IL-1 beta, IL-6 and TNF-alpha in runners.
长期运动和高脂饮食与免疫抑制有关。我们已经报道了饮食脂肪水平和运动对跑步者外周血单个核细胞淋巴细胞亚群、增殖反应及细胞因子体外产生的影响。本研究旨在进一步探讨饮食脂肪的作用机制是否是通过调节跑步者血浆细胞因子来实现的。
本研究比较了女性（N = 8 - 10）和男性（N = 8 - 10）跑步者在食用含17%（低脂，LF）、32%（中脂，MF）和41%（高脂，HF）脂肪的饮食（每种饮食4周）后，静息状态及在80%最大摄氧量（V02max）下进行耐力运动后的血浆细胞因子水平。
白细胞介素 - 1β（IL - 1β）水平与性别、运动及饮食脂肪水平无关。男性跑步者血浆中肿瘤坏死因子（TNF - α）水平高于女性，且这两种细胞因子的水平随饮食脂肪水平的升高而增加。血浆白细胞介素 - 2（IL - 2）水平（一种参与增强T细胞宿主防御功能的细胞因子）在男性跑步者中显著高于女性，且男性中随着饮食脂肪增加而降低。耐力运动后血浆白细胞介素 - 6（IL - 6）水平显著降低，且IL - 6水平随饮食脂肪增加而降低。
本研究数据表明，饮食脂肪对跑步者血浆细胞因子水平有不同影响。提高饮食脂肪水平显著增加了耐力运动时间，且对跑步者血浆IL - 2及促炎细胞因子（IL - 1β、IL - 6和TNF - α）水平无不良影响。
