Kucera M L, Graham J P
Veterans Affairs Medical Center, Amarillo, Texas, USA.
Pharmacotherapy. 1998 May-Jun;18(3):526-38.
Insulin lispro is a rapid-acting insulin analog to regular insulin. Inversion of the proline-lysine amino acid sequence at positions 28 and 29 on the B chain is responsible for its more rapid absorption, faster onset, and shorter duration of action compared with regular insulin. The fast onset of action allows for greater flexibility in dosing and mealtime scheduling. Insulin lispro provides equivalent or slightly improved glycemic control in patients with types I and II diabetes mellitus compared with regular insulin, without subsequent increases in hypoglycemic episodes. It also results in greater reduction in postprandial blood glucose excursion than regular insulin. Compared with other insulins, insulin lispro represents a more physiologic approach to exogenous insulin therapy.
赖脯胰岛素是一种与常规胰岛素相比的速效胰岛素类似物。B链上第28和29位的脯氨酸-赖氨酸氨基酸序列倒置，使其与常规胰岛素相比吸收更快、起效更快、作用持续时间更短。快速起效使得给药和进餐时间安排更具灵活性。与常规胰岛素相比，赖脯胰岛素在I型和II型糖尿病患者中能提供同等或稍好的血糖控制，且不会随后增加低血糖发作次数。它还能比常规胰岛素更有效地降低餐后血糖波动。与其他胰岛素相比，赖脯胰岛素代表了一种更符合生理的外源性胰岛素治疗方法。
