Noble S L, Johnston E, Walton B
University of Mississippi Medical Center, Jackson, USA.
Am Fam Physician. 1998 Jan 15;57(2):279-86, 289-92.
Research has established the importance of maintaining blood glucose levels near normal in patients with type 1 (insulin-dependent) diabetes mellitus. Short-acting insulin analogs are designed to overcome the limitations of regular short-acting insulins. Compared with regular human insulin, the analog insulin lispro offers faster subcutaneous absorption, an earlier and greater insulin peak and a more rapid postpeak decrease. Insulin lispro begins to exert its effects within 15 minutes of subcutaneous administration, and peak levels occur 30 to 90 minutes after administration. Duration of activity is less than five hours. Rates of insulin allergy, lipodystrophy, hypoglycemia and abnormal laboratory test results are essentially the same in patients using insulin lispro and in those using regular human insulin.
研究已证实，对于1型（胰岛素依赖型）糖尿病患者，将血糖水平维持在接近正常范围十分重要。短效胰岛素类似物旨在克服常规短效胰岛素的局限性。与常规人胰岛素相比，胰岛素类似物赖脯胰岛素皮下吸收更快，胰岛素峰出现更早、更高，峰后下降更快。赖脯胰岛素皮下给药后15分钟内开始起效，给药后30至90分钟达到峰值水平。作用持续时间少于5小时。使用赖脯胰岛素的患者与使用常规人胰岛素的患者相比，胰岛素过敏、脂肪营养不良、低血糖及实验室检查结果异常的发生率基本相同。
