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9-Hydroxycrisamicin A, a new cytotoxic isochromanquinone antibiotic produced by Micromonospora sp. SA246.

作者信息

Yeo W H, Yun B S, Back N I, Kim Y H, Kim S S, Park E K, Whang K S, Yu S H

机构信息

Korea Ginseng & Tobacco Research Institute, Taejon, Korea.

出版信息

J Antibiot (Tokyo). 1997 Jul;50(7):546-50. doi: 10.7164/antibiotics.50.546.

DOI:10.7164/antibiotics.50.546
PMID:9711245
Abstract

9-Hydroxycrisamicin A, a new cytotoxic isochromanquinone antibiotic, was isolated from a soil microorganism SA246 which was identified as Micromonospora sp. The molecular formula of 9-hydroxycrisamicin A was determined as C32H22O13 based on the HRFAB-MS analysis, and the structure was determined by various NMR experiments. 9-Hydroxycrisamicin A showed weak antimicrobial activity against Gram-positive bacteria and strong cytotoxic activity against some human cancer cell lines such as SK-OV-3 (ovarian), HCT15 (colon), SK-MEL-2 (melanoma), A549 (lung), XF498 (central nervous system) with ED50 of 0.47-0.65 microgram/ml.

摘要

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