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刺孢霉素，一类新型抗肿瘤抗生素：分类学、发酵及生物学特性

Calicheamicins, a novel family of antitumor antibiotics: taxonomy, fermentation and biological properties.

作者信息

Maiese W M, Lechevalier M P, Lechevalier H A, Korshalla J, Kuck N, Fantini A, Wildey M J, Thomas J, Greenstein M

机构信息

Medical Research Division, American Cyanamid Company, Lederle Laboratories, Pearl River, New York 10965.

出版信息

J Antibiot (Tokyo). 1989 Apr;42(4):558-63. doi: 10.7164/antibiotics.42.558.

DOI:10.7164/antibiotics.42.558
PMID:2722671
Abstract

A novel family of antitumor antibiotics, the calicheamicins, were isolated from the fermentation broth of Micromonospora echinospora subsp. calichensis. These antibiotics exhibited significant activity against Gram-positive and Gram-negative bacteria in vitro. Calicheamicin gamma 1I demonstrated antitumor activity against P388 leukemia and B16 melanoma in vivo.

摘要

一类新型抗肿瘤抗生素——刺孢霉素，是从栖土放线菌微小单孢菌亚种的发酵液中分离得到的。这些抗生素在体外对革兰氏阳性菌和革兰氏阴性菌均表现出显著活性。刺孢霉素γ1I在体内对P388白血病和B16黑色素瘤显示出抗肿瘤活性。

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