Ohkuma H, Naruse N, Nishiyama Y, Tsuno T, Hoshino Y, Sawada Y, Konishi M, Oki T
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
J Antibiot (Tokyo). 1992 Aug;45(8):1239-49. doi: 10.7164/antibiotics.45.1239.
Streptomyces roseiscleroticus L827-7 (ATCC 53903) produced a novel antifungal and antitumor antibiotic, sultriecin. It exhibited in vitro antifungal activity and potent in vivo antitumor activity against P388 and L1210 leukemias, and B16 melanoma. Sultriecin is composed of several unique structural units; a conjugated triene, an alpha,beta-unsaturated delta-lactone, and a sulfate functionality.
玫瑰硬皮链霉菌L827 - 7（ATCC 53903）产生了一种新型抗真菌和抗肿瘤抗生素——磺菌素。它在体外表现出抗真菌活性，并且对P388和L1210白血病以及B16黑色素瘤具有强大的体内抗肿瘤活性。磺菌素由几个独特的结构单元组成；一个共轭三烯、一个α,β - 不饱和δ - 内酯和一个硫酸酯官能团。
