Baker P, Piven J, Sato Y
Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City 52242, USA.
J Autism Dev Disord. 1998 Aug;28(4):279-85. doi: 10.1023/a:1026004501631.
This study employed a hierarchical assessment to detect the prevalence of autism in a clinic sample of individuals with tuberous sclerosis complex (TSC). After screening subjects with the Autism Behavior Checklist, subsequent evaluations with the Autism Diagnostic Interview, and direct clinical observation, the prevalence of autistic disorder in this sample of 20 subjects was conservatively estimated at 20%. Data suggest a possible association between both hypsarrythmia and TSC-related cardiac abnormalities with autism in this subgroup of TSC individuals. Implications of these findings for clinical practice and further research are discussed.
本研究采用分层评估方法，以检测结节性硬化症（TSC）患者临床样本中自闭症的患病率。在用自闭症行为检查表对受试者进行筛查后，随后使用自闭症诊断访谈并进行直接临床观察，在这20名受试者的样本中，自闭症谱系障碍的患病率保守估计为20%。数据表明，在该结节性硬化症亚组个体中，癫痫性痉挛和TSC相关心脏异常均与自闭症可能存在关联。讨论了这些发现对临床实践和进一步研究的意义。
