与高持续 +Gz 相关的心脏病理学：II. 应激性心肌病。
Cardiac pathology associated with high sustained +Gz: II. Stress cardiomyopathy.
作者信息
MacKenzie W F, Burton R R, Butcher W I
出版信息
Aviat Space Environ Med. 1976 Jul;47(7):718-25.
The myocardial pathology of 14 pigs exposed to HSGz stress of 9 and 15, or 3, 7, and 9 Gz was studied; six control pigs were used as comparisons. Four pigs received propranolol prior to centrifugation and four pigs received atropine. Hearts were studied by light and electron microscopy. Myocardium from stressed pigs showed myofibrillar degeneration, pooling of mitochondria, and cell death. Lesions occurred in random cells of the subendocardium and papillary muscles. Purkinje fibers were also involved. Pretreatment with atropine increased the number of dead cells found and propranolol increased the number of cells showing myofibrillar degeneration. It is postulated that this is a pluricausal cardiomyopathy similar to several experimental conditions. Significance to aerospace medicine is briefly discussed.
研究了14头暴露于9Gz和15Gz或3Gz、7Gz和9Gz的高过载（HSGz）应激下的猪的心肌病理学；使用6头对照猪作为比较。4头猪在离心前接受了普萘洛尔，4头猪接受了阿托品。通过光学显微镜和电子显微镜对心脏进行了研究。应激猪的心肌显示出肌原纤维变性、线粒体聚集和细胞死亡。病变发生在内皮下层和乳头肌的随机细胞中。浦肯野纤维也受到影响。阿托品预处理增加了发现的死亡细胞数量，普萘洛尔增加了显示肌原纤维变性的细胞数量。据推测，这是一种类似于几种实验条件的多病因心肌病。简要讨论了其对航空航天医学的意义。
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