McNutt N S
Department of Pathology, New York Hospital-Cornell University Medical Center, NY 10022, USA.
Semin Diagn Pathol. 1998 Aug;15(3):203-9.
Nevoid malignant melanoma probably represents an early form of nodular malignant melanoma in which there is little proliferation of melanocytes in the epidermis and a dermal proliferation that mimics some features of a compound or intradermal nevus, which is difficult to recognize as being due to malignant melanoma. The lesions can contain either small nevoid cells or larger cells that resemble those in Spitz's nevi. Overall the lesions are symmetrical, have minimal proliferation in the epidermis, and often have dispersion of cells at the base. The lesions with small nevoid cells are particularly difficult to distinguish from common intradermal or compound melanocytic nevi. Reactivity of the intradermal component for HMB-45 antigen, without antigen retrieval, or for Ki-67 antigen can show that the dermal cells have an immature phenotype and, in combination with histological criteria, can support a diagnosis of nevoid malignant melanoma.
无痣恶性黑色素瘤可能代表结节性恶性黑色素瘤的一种早期形式，其中表皮内黑素细胞增殖很少，真皮内增殖类似于复合痣或皮内痣的某些特征，难以识别为恶性黑色素瘤所致。病变可包含小的无痣细胞或类似于斯皮茨痣中的较大细胞。总体而言，病变对称，表皮内增殖极少，且细胞常在底部分散。含有小无痣细胞的病变尤其难以与常见的皮内或复合性黑素细胞痣区分开来。皮内成分对HMB - 45抗原（无需抗原修复）或Ki - 67抗原的反应性可显示真皮细胞具有未成熟表型，结合组织学标准，可支持无痣恶性黑色素瘤的诊断。
