Petty R E, Hunt D W
Department of Pediatrics, University of British Columbia, Vancouver, Canada.
Vaccine. 1998 Aug-Sep;16(14-15):1378-82. doi: 10.1016/s0264-410x(98)00095-4.
The capacity of lymphoid dendritic cells from human cord blood or adult peripheral blood to support a mixed leukocyte reaction in cord blood and adult T cells has been compared. Cord blood dendritic cells have a limited ability to induce either adult or cord blood T cells to proliferate in response to typical concentration of phytohemagglutinin or concanavalin A. Adult blood dendritic cells, on the other hand, induce equivalent mitogen responses in cord blood and adult blood T cells. This relative deficiency can be overcome by increasing the concentration of mitogen or the numbers of dendritic cells in the culture. Neonatal primary immune responses may, in part, reflect the reduced function of dendritic cells.
对来自人脐带血或成人外周血的淋巴样树突状细胞支持脐带血和成人T细胞混合淋巴细胞反应的能力进行了比较。脐带血树突状细胞诱导成人或脐带血T细胞在典型浓度的植物血凝素或刀豆球蛋白A刺激下增殖的能力有限。另一方面，成人血树突状细胞可诱导脐带血和成人血T细胞产生同等的有丝分裂原反应。通过增加培养中有丝分裂原的浓度或树突状细胞的数量，可以克服这种相对缺陷。新生儿的初级免疫反应可能部分反映了树突状细胞功能的降低。
