Lin W Y, Cheng K Y, Wang S J
Department of Nuclear Medicine, Taichung Veterans General Hospital, and Chung-Tai College of Medical Technology, Taiwan.
Clin Nucl Med. 1998 Aug;23(8):517-20. doi: 10.1097/00003072-199808000-00005.
Lupus nephritis is a disease characterized by flareups and remissions. Evaluation of disease activity is important for therapeutic decisions and prognosis. In this study, 46 patients with lupus nephritis were evaluated by Ga-67 scintigraphy. Delayed 48-hour Ga-67 images were performed to evaluate kidney uptake. A patient with a 24-hour urinary protein excretion of 3 g or more or a serum creatinine level greater than 1.5 mg/dl was considered to have active lupus nephritis. Renal disease was active in 22 patients and inactive in 24 patients. Of the 22 patients with active renal disease, 18 (81.8%) showed positive Ga-67 results, whereas only 12.5% (3 of 24) of patients with inactive renal disease showed a positive Ga-67 study. The difference between the two groups was significant. Patients with positive Ga-67 scans had a significantly higher serum creatinine level and 24-hour urine protein value than patients with negative Ga-67 scans. In addition, all of the patients (100%) with a 24-hour urine protein greater than 4 g/day had a positive Ga-67 scan. It appears that Ga-67 scintigraphy is useful for the evaluation of disease activity in lupus nephritis.
狼疮性肾炎是一种以病情发作和缓解为特征的疾病。评估疾病活动度对于治疗决策和预后很重要。在本研究中，46例狼疮性肾炎患者接受了镓-67闪烁扫描评估。进行了48小时延迟镓-67图像以评估肾脏摄取情况。24小时尿蛋白排泄量3g或更多或血清肌酐水平大于1.5mg/dl的患者被认为患有活动性狼疮性肾炎。22例患者的肾脏疾病为活动期，24例为非活动期。在22例活动性肾脏疾病患者中，18例（81.8%）镓-67结果为阳性，而在非活动性肾脏疾病患者中只有12.5%（24例中的3例）镓-67检查结果为阳性。两组之间的差异具有显著性。镓-67扫描阳性的患者血清肌酐水平和24小时尿蛋白值显著高于镓-67扫描阴性的患者。此外，所有24小时尿蛋白大于4g/天的患者（100%）镓-67扫描均为阳性。看来镓-67闪烁扫描对于评估狼疮性肾炎的疾病活动度是有用的。
