CR4在无血清情况下对结核分枝杆菌与人巨噬细胞结合及信号转导中的作用。
Role of CR4 in Mycobacterium tuberculosis-human macrophages binding and signal transduction in the absence of serum.
作者信息
Zaffran Y, Zhang L, Ellner J J
机构信息
Department of Medicine, Case Western Reserve University, and University Hospitals, Cleveland, Ohio 44106-4984, USA.
出版信息
Infect Immun. 1998 Sep;66(9):4541-4. doi: 10.1128/IAI.66.9.4541-4544.1998.
Abstract
The beta2 integrin CR4 is involved in Mycobacterium tuberculosis phagocytosis by human mononuclear phagocytes through the opsonin C3bi. In this study, we demonstrate that M. tuberculosis can bind directly to monocyte-derived macrophages via CR4 in the absence of any opsonins. CR4-transfected CHO cells gave similar results, suggesting recognition by CR4 of bacterial structure. Furthermore, binding of M. tuberculosis transduced a potent signal, resulting in tyrosine phosphorylation of macrophage proteins, which was in part mediated by CR4.
摘要
β2整合素CR4通过调理素C3bi参与人单核吞噬细胞对结核分枝杆菌的吞噬作用。在本研究中，我们证明，在没有任何调理素的情况下，结核分枝杆菌可通过CR4直接与单核细胞衍生的巨噬细胞结合。转染CR4的CHO细胞也得到了类似结果，表明CR4可识别细菌结构。此外，结核分枝杆菌的结合传导了一个有效的信号，导致巨噬细胞蛋白的酪氨酸磷酸化，这部分是由CR4介导的。
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