巨噬细胞诱导基因mig作为鸟分枝杆菌复合群菌株临床致病性和体外毒力的标志物。
The macrophage-induced gene mig as a marker for clinical pathogenicity and in vitro virulence of Mycobacterium avium complex strains.
作者信息
Meyer M, von Grünberg P W, Knoop T, Hartmann P, Plum G
机构信息
Institut für Medizinische Mikrobiologie und Hygiene, Universität zu Köln, D-50935 Cologne, Germany.
出版信息
Infect Immun. 1998 Sep;66(9):4549-52. doi: 10.1128/IAI.66.9.4549-4552.1998.
Abstract
The capacity of 20 Mycobacterium avium complex isolates to multiply intracellularly in human monocyte-derived macrophages was assessed and correlated to the clinical relevance of each isolate and its reactivity with several candidate genetic virulence markers. The strongest correlation with a virulence phenotype was found for a conserved coding sequence of the macrophage-induced gene mig identified by a specific mig restriction fragment length polymorphism type.
摘要
评估了20株鸟分枝杆菌复合群分离株在人单核细胞衍生巨噬细胞内繁殖的能力，并将其与各分离株的临床相关性及其与几种候选基因毒力标记的反应性相关联。通过特定的迁移限制片段长度多态性类型鉴定的巨噬细胞诱导基因mig的保守编码序列与毒力表型的相关性最强。
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